GSK3B and early-onset autosomal dominant Alzheimer disease: The results showed that GSK3β expression was significantly related to four clinical traits in AD including “Braak neurofibrillary tangle score,” “Average neuritic plaque density,” “Sum of Consortium to Establish a Registry for Alzheimer's Disease rating scores in multiple brain regions” and “Sum of neurofibrillary tangle density in multiple brain regions” (Figure 3A‐D).