APP and Alzheimer disease: Oestrogens is found to be involved in cognition and memory and also contribute to gender‐related differences in AD.41 After menopause, the decline of oestrogen levels in the brain may make neurons more susceptible to age‐related neurodegenerative processes.42 Yue et al24 found that, compared with APP23 transgenic control mice, oestrogen‐deficient APP23 mice exhibited greatly reduced brain oestrogen and early onset and increased beta amyloid peptide (Abeta) deposition.