The regulatory mechanism is described as competing endogenous RNA (ceRNA) theory.25, 26, 27, 28 LncRNAs harbour miRNAs and absorb dissociative miRNAs, decreasing the abundance in cells.29, 30 For instance, lncRNA NR2F1‐AS1 promoted ABCC1 expression through endogenous sponging miR‐363 to regulate hepatocellular carcinoma HCC oxaliplatin‐resistance.31 In this study, we found that SNHG20 functioned as a “sponge” for miR‐197, meanwhile, miR‐197 also targeted LIN28, forming a whole regulatory pathway. The gene discussed is NR2F1; the disease is hepatocellular carcinoma.