It has been reported that Metrnl could improve insulin sensitivity and was correlated with metabolic parameters, including fasting glucose, fasting insulin, postload 2 hours glucose, HbA1c, and lipid levels.21 We thus hypothesized that the role of Metrnl as an insulin sensitizer might affect the predictive value of Metrnl for CAD in patients with diabetes. Here, INS is linked to diabetes mellitus.