CALR and neoplasm: These effects were similar to those of ATRA.40, 41 The use of ATRA with arsenic trioxide or chemotherapeutic agents, or both of these agents, composes the main treatment strategy of APL, a subtype of AML.25, 42 Western blot showed up‐regulation of CRT and down‐regulation of C/EBPα protein expression in tumour tissues.