SIRT1 and atherosclerosis: SIRT1, an important anti‐atherosclerosis molecule, protects the cardiovascular system from degeneration and oxidative injuries.31, 32 Previous reports have suggested that SIRT1 activation is an effective approach to manage HHcy‐induced oxidative stress,33, 34 and SIRT1 decreased the LOX‐1 expression level and NF‐κB activation.8, 25 This statement is similar to our findings in the present study, as shown in Figures 4B and 7C, Hcy decreased SIRT1 expression significantly.