APOE4 astrocytes also produce more CCL3 (chemokine C‐C motif ligand 3) 113, similar to microglial Ccl3 mRNA upregulation in AD‐like models 92, which is downstream of the APOE‐driven network while APOE‐/‐ mice produce less CCL3 109. The gene discussed is CCL3; the disease is Alzheimer disease.