Microglia induced with LPS in the APOE4 background released greater amounts of pro‐inflammatory cytokines, like tumour necrosis factor‐α (TNF‐α), IL‐1β, and interleukin‐6 (IL‐6) 106, an effect replicated in AD‐like models 88, 107. The gene discussed is IL1B; the disease is Alzheimer disease.