WRN and osteoporosis: During his teens, he gradually began to develop gray hair, atrophic skin, change in his voice, osteoporosis and short stature, features that are seen in other progeroid syndromes, including the classical Werner syndrome, a recessive segmental progeroid syndrome caused by null mutations of WRN, a member of the RECQ family of DNA helicases (Oshima, Martin, & Hisama, 2016).