Bone scintigraphy using (99m)Tc-3,3-diphosphono-1,2-propanodicarboxylic acid ((99m)Tc-DPD) or similar has become the gold standard for the diagnosis of TTR related cardiac amyloidosis with a specificity and positive predictive value of 100% when grade 2 or 3 myocardial radiotracer uptake on bone scintigraphy was found, in absence of a monoclonal protein in serum or urine23. This evidence concerns the gene TTR and cardiac amyloidosis.