In young patients with typical asymmetrical septal hypertrophy, the evaluation of the main sarcomeric genes (i.e., MYH7, MYBPC3, TNNT2, TNNI3, ACTC, MYL2, MYL3, TPM1 and TNNC) usually identified a disease causing variant in approximately 60% of the cases, while the yield of the same test in elderly patients with a septal bulge, or with concentric hypertrophy was much lower (between 10 and 30%)19. Here, TPM1 is linked to Asymmetric septal hypertrophy.