Importantly, the enhancement of T-cell anergy induced by glioma cells treated with MLN4924 was inhibited in the presence of PD1/PDL1 inhibitor-#1 (Figure 4), suggesting that PD1/PDL1 interaction is the main signaling path involved in T-cell anergy after glioma cell treatment with MLN4924. The gene discussed is CD274; the disease is glioma.