2004). SHI is an active component extracted from Radix Arnebiae and possesses anti-inflammatory properties (Fu et al. 2016). Previous study has shown that SHI inhibits the inflammatory responses in IL-1β- and TNF-α-stimulated hPDLCs (Shindo et al. 2016), suggesting the potential use of SHI as an anti-inflammatory agent against periodontitis. The gene discussed is TNF; the disease is periodontitis.