PRKN and Parkinson disease: PD is characterized by progressive degeneration and decay of dopaminergic neurons of the nigrostriatal path and, to a lesser extent, of the mesocorticolimbic and hippocampal path and, with variable intensity, noradrenergic, serotoninergic as well as cholinergic neurons, due to the deposition of insoluble protein aggregates, such as α-synuclein (αSyn) and parkin, forming so-called Lewy’s bodies in the cytoplasm [60].