CSF AD core biomarkers did not have a significant impact and their inclusion and subsequent adjustment did not influence the effect size (β) of delirium (ln(CSF sTREM2: delirium β1 = − 0.47, p = 0.02; CSF p-tau β2 = 0.000, p = 0.97; CSF Aβ42 β3 = 0.000, p = 0.16; age β4 = 0.013, p = 0.13, n = 57). The gene discussed is MAPT; the disease is Alzheimer disease.