Whereas most known relevant anti-neuronal antibodies are of the IgG isotype, the results of pathogenicity studies of NMDAR IgA and IgM antibodies show their pathogenic potential in vitro [5, 24, 35, 36] and in a study of patients with stroke [37], although authors from another study concluded that NMDAR IgA and IgM antibodies do not alter NMDAR levels [38]. The gene discussed is CD40LG; the disease is Stroke.