For example, CHD7 is associated with CHARGE syndrome, which can include craniofacial defects such as a small mouth, and cleft lip and/or cleft palate and are the result of problems in neural crest development [44, 45] In addition to CHD family members, our analysis uncovered other chromatin readers and remodelers including ATRX [46], BRD4 (MGI) and MTA2 [47] that are also associated with craniofacial birth defects. This evidence concerns the gene ATRX and medical procedure.