MMS19 and adenocarcinoma: Among the 3548 positive aGRP DEGs, for example, MMS19 (aGRP = 0.69) is a DNA repair gene playing important role in Nucleotide Excision Repair (NER) pathway, whose single nucleotide polymorphism, rs3740526 has been reported to significantly distinguish adenocarcinoma with squamous cell carcinoma and whose expression levels are clinically related with ACT benefit of resected non-small cell lung cancer patients [43, 44].