SPRY4 and rhabdomyosarcoma: In addition, miR-411-5p was reduced by transforming growth factor (TGF)-β1 [34] in rhabdomyosarcoma (RMS); thus, the self-regulated loop between TGF-β1/miR-411-5p/SPRY4 and MAPK was formed, and not only activated p38/MAPK phosphorylation but also promoted apoptosis and myogenic differentiation via direct downregulation of SPRY4 in RMS [35].