SOAT1 and HIV-1 infection: Moreover, HIV-1 infection altered distinct signature pathways in the brains of HIV-transgenic rats including B-cell translocation gene (BTG) family-mediated cell cycle regulation and toll-like receptor signaling in the prefrontal cortex, and JAK/STAT signaling and eukaryotic initiation factor 2 signaling in the hippocampus and striatum, respectively29.