A qRT-PCR lipid metabolism array revealed the upregulation of several genes that are implicated in the biogenesis of β-amyloid and Alzheimer’s disease (AD), including sterol o-acyltransferase 1/acetyl-coenzyme A acyltransferase 1 (SOAT1/ACAT1), sortilin-related receptor, L1 (SORL1) and low-density lipoprotein receptor-related protein 12 (LPR12). The gene discussed is ACAT1; the disease is early-onset autosomal dominant Alzheimer disease.