To determine the long-term engraftment potential of TRIAMF treated HSPCs, we injected untreated HSPCs and TRIAMF treated HSPCs with or without RNPs into sub-lethally irradiated non-obese (NOD)/severe combined immunodeficiency (SCID)/Il2rg−/− (NSG) mice. The gene discussed is IL2RG; the disease is severe combined immunodeficiency.