Thus, our collective evidence from clinical testing, including semen analysis, endocrinology, ultrasonography, histopathology, and genetics, coupled with segregation analysis of family members, presents convincing evidence for the ADGRG2 mutation as a cause of obstructive azoospermia and offers new insight into how ADGRG2 may cause OA. Here, ADGRG2 is linked to Azoospermia.