To assess the effect of inflammation on CD86 and PD-L1 expression, we stained an HLA-DR-positive active demyelinating MS lesion and found microglia-like cells to stain positive for CD86 (Fig. 7i) and reactive astrocyte-like cells to stain positive for PD-L1 (Fig. 7j). The gene discussed is CD86; the disease is myeloid sarcoma.