We found significantly reduced expression of immunosuppressive genes, arginase 1 (Arg1) and indoleamine 2,3-dioxygenase (Ido), in female LR/Stat3Δ/Δ mice relative to CC-LR littermates (Fig. 3b) suggestive of reduced pro-tumor type 2 macrophage polarization and myeloid derived suppressor cells (MDSCs) responses and enhanced T-cell activation. This evidence concerns the gene IDO2 and neoplasm.