A mechanistic network comprising beta-estradiol signaling (P-value of overlap = 6.8 × 10−5; Supplementary Figure 4) was activated in female mice with epithelial Stat3 deletion and that comprised elevated expression of T-cell markers (CD4 and CD3); suggesting potential cues linking estrogen signaling activation and anti-tumor immune mechanisms. Here, STAT3 is linked to neoplasm.