This effect was accompanied by significantly decreased expression of Il6 and Cxcl1 levels as well as markedly and significantly increased expression of the anti-tumor and/or cytotoxic immune genes nitric oxide synthase 2 (Nos2), Ifng, T-box transcription factor 21 (Tbx21), and Gzmb (Fig. 4c). Here, CXCL1 is linked to neoplasm.