Further, blockade of IL-6 in male mice significantly inhibited lung tumorigenesis with concomitant reformatting of the lung TME toward an anti-tumor phenotype characterized by an increased expression of the cytotoxic immune response (e.g. Gzmb) and a decreased expression of Tgfb and Foxp3, markers of tumor-promoting Treg response27. This evidence concerns the gene GZMB and neoplasm.