Using sequencing data from Project GENIE, which contains 453 PDGFRA missense mutations from over 18,000 samples across 37 tumor types, we discovered that over 50% of PDGFRA missense mutations were located in the extracellular domain in glioma and colorectal cancer (Fig. 1b and Supplementary Data 2). Here, PDGFRA is linked to central nervous system cancer.