TP53BP2 and neoplasm: Notably, reduced expression of ASPP2 was significantly associated with advanced TNM stage (χ2 = 33.513, P < 0.001), lymph node metastasis (χ2 = 19.415, P < 0.001), and poor tumor differentiation (χ2 = 25.222, P < 0.001) in GBC (Fig. 1b and Table 1).