MEN1 and pituitary tumor: Our study has revealed that (1) the expression of the microRNAs miR-15a, miR-16-1 and let-7a are downregulated in pituitary tumours that develop in a Men1+/− mouse model; (2) there is a significant positive correlation between miR-15a and miR-16-1 expression; (3) the decreased miR-15a and miR-16-1 expression is associated with increased cyclin D1 expression and (4) that loss of menin expression is associated with a decrease in miR-15a expression.