CCND1 is reported to be regulated by miR-15a/miR-16-1 in prostate and non-small-cell lung cancer (Cimmino et al. 2005, Bonci et al. 2008, Calin et al. 2008, Bandi et al. 2009, Croce 2009, Salerno et al. 2009), and we therefore examined CCND1 expression in the pituitary of the Men1+/− mice that had reduced expression of miR-15a and miR-16-1 (Fig. 1A, B and C). The gene discussed is CCND1; the disease is non-small cell lung carcinoma.