Quantitative RT-PCR analysis of pituitary tumours isolated from Men1+/− mice or normal pituitary tissue isolated from WT mice, revealed the pituitary tumours, when compared to normal pituitaries, to have a significant decrease in the expression of miR-15a (2.3-fold, P < 0.05), miR-16-1 (2.1-fold P < 0.01) and let-7a (1.6-fold P < 0.05) (Fig. 1A, B and C). The gene discussed is MEN1; the disease is pituitary tumor.