MEN1 and pituitary tumor: This observed downregulation of miR-15a, miR16-1 and let-7a in the Men1+/− pituitary tumours was consistent with their reported reduced expressions in human pituitary tumours (Bottoni et al. 2005, 2007, Amaral et al. 2009, Qian et al. 2009, D’Angelo et al. 2012, Palmieri et al. 2012).