The observation of increased cyclin D1 protein expression in association with down regulation of miR-15a and miR-16-1 in pituitary tumours from Men1+/− mice (Fig. 2), suggests that cyclin D1 is a putative target of miR-15a and miR-16-1 in these Men1-associated pituitary tumours. The gene discussed is CCND1; the disease is pituitary tumor.