IL2 and type 1 diabetes mellitus: Results from a recent adaptive dose-finding study in 40 patients with type 1 diabetes suggest that the optimal dose of a single injection of IL-2 that will induce 10% and 20% increases in Tregs over 7 days were approximately 0.10×106 IU/m2 and 0.5×106 IU/m2, respectively.140 This study also showed that the mean plasma concentrations of IL-2 at 90 min postinjection, even at the lowest doses, were higher than the hypothetical Treg-specific therapeutic window determined in vitro (0.015–0.24 IU/mL).