IL2 and type 1 diabetes mellitus: A follow-on study by the same group investigated the optimum frequency of administration of IL-2 in type 1 diabetes.141 Results show that the optimum regimen to maintain a steady state increase in Treg of 30% and CD25 expression of 25% without Teff expansion was 0.26×10 IU/m2 every 3 days.142