Further studies in experimental MS buttressed this finding57–60 and showed that MSCs control disease through inhibition of CD4+ Th17 T cells,58 generation of CD4+CD25+FoxP3+ Tregs60 and through hepatocyte growth factor production.59 Therapeutic efficacy was also observed in the MRL/Lpr61 and NZB/W F162 63 mouse models of SLE. Here, CD4 is linked to systemic lupus erythematosus.