The absence of mutations in NOTCH1, SGCE, WDR88, MAST3, PCDH15, and COL6A3 in the primary leukemias (P1INI, P5INI, P10INI, P10REL, and P12REL) was validated by Sanger sequencing as shown in Appendix Fig S5B. Here, NOTCH1 is linked to leukemia.