Next, we activated mGPDH via AAV in mdx mice, which represent a model of Duchenne muscular dystrophy, in which there is a persistent damage and loss of myofibers induced by the Dmd gene mutation (Barton et al, 2002; Duddy et al, 2015; Novak et al, 2017). This evidence concerns the gene GPD2 and Duchenne muscular dystrophy.