YME1L1 and cerebellar ataxia: Our loss‐of‐function model for YME1L in the nervous system therefore recapitulates some clinical features of a neuromuscular disorder that is caused by homozygous missense mutations in YME1L and characterized by developmental delay, ocular dysfunction, ataxia and athetotic and stereotypic movements (Hartmann et al, 2016).