Pharmacologically, either lentiviral over-expression of miR-30 or liver-directed delivery of a miR-30 mimic mitigated hypercholesterolaemia and aortic atherosclerosis in Apoe KO mice, without inducing hepatosteatosis (an undesirable side effect of conventional MTTP inhibitors) by diminishing hepatic lipid synthesis [39,40]. This evidence concerns the gene APOE and aortic atherosclerosis.