Conversely, bone marrow transplantation studies conducted in Ldlr deficient mice revealed hematopoietic miR-155 deficiency accelerated atherogenesis and therefore intimates that miR-155 exerts anti-inflammatory and athero-protective effects particularly during hypercholesterolaemia and is associated with suppression of circulating inflammatory monocyte numbers and restoration of IL-10 production [60]. Here, LDLR is linked to Hypercholesterolemia.