The angiotensin II (Ang II)-infused hypercholesterolaemic mouse model and the calcium chloride peri-vascular application model are the most commonly utilised for mechanistic AAA studies [97], and have been deployed to ascertain the contributory roles of select microRNA to aortic aneurysm formation and progression (summarised in Table 2). The gene discussed is AGT; the disease is aortic aneurysm.