The Amyloid precursor protein (APP) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) genes, located within the triplicated human chromosome 21 (Hsa21) (Korenberg et al., 1990; Rueda et al., 2012) are overexpressed in DS individuals. The gene discussed is DYRK1A; the disease is Dravet syndrome.