MAPT and Alzheimer disease: AD is cerebrally manifested by accumulation of extracellular deposits of Amyloid-β (Aβ) in form of plaques (Goedert, 2015), neuritic plaques (Mattson, 2004), elevated levels of neurotoxic Aβ oligomers (Benilova et al., 2012), cerebral amyloidic angiopathy (Ghiso et al., 2010) and intraneuronal accumulation of hyperphosphorylated tau protein in from of tangles (Goedert, 2015).