Luminal A subtype, like the MCF-7 cell line, is the most frequent breast cancer subtype that is low grade, tends to grow slowly and has the highest survival rate, whereas triple-negative, similar to MDA-MB-468, is less common breast cancer subtype, has the lowest survival rate, has very high aggressive potentials and is difficult to treat because no hormone receptor has been found to target yet. The gene discussed is NR4A1; the disease is breast cancer.