CALR and leukemia: It proved the concept that imidazo[1,2-b]pyrazole-7-carboxamides perturb the homeostasis of leukemia cells; nine genes (GDF15, ATF3, LGALS1, LBR, GADD153, UBC, BCL2A1, HSPA1A, CALR) associated with drug induced cytotoxicity have been significantly upregulated after 12 h stimulation (Figure 3B).