Pro-survival protein Mcl-1 and pro-oncoprotein c-Myc are critical regulators that promote the survival of leukemia cells; HHT could affect the survival of leukemia cells by allowing the rapid loss of short-lived Mcl-1 and c-Myc to facilitate proapoptotic triggering [19,20,21,22,23]. The gene discussed is MCL1; the disease is leukemia.