In the present study, we sought associations of five obesity-related CNV loci [1p31.1/NEGR1 (Neuronal growth regulator 1), 10q11.22/GPRC5B (G Protein-Coupled Receptor Class C Group 5 Member B), 11q11/OR4P4/OR4S2/OR4C6, 16p12.3/NPY4R (Neuropeptide Y Receptor Y4) and 1p21.1/AMY1] with obesity risk in the Mexican population. The gene discussed is OR4S2; the disease is obesity due to melanocortin 4 receptor deficiency.