The lack of association of the 1p31.1/NEGR1 CNV is in agreement with previous reports in Mexican children and adults where rs2815752 (in high LD with 1p31.1/NEGR1 CNV) was not associated with obesity [12,38], but in disagreement with the findings of Antúnez-Ortiz et al. who found a significant association of another NEGR1 CNV in a group of Mexican children [39]. The gene discussed is NEGR1; the disease is obesity due to melanocortin 4 receptor deficiency.