EGFR and triple-negative breast carcinoma: Generation 4 PAMAM (PAMAM-G4) was used as macroinitiator for the formation of PLA arms followed by PEG conjugation and final grafting with the GE11 peptide, which targets epidermal growth factor receptor (EGFR), i.e., a protein which is frequently overexpressed in triple negative breast cancer (TNBC) tumors [84].