Clearly, as the characteristics of glioma with IDH mutations are related to both the inactivation of several tumor suppressor genes and the overexpression of other genes, although it should be noted that G0S2 is not an only marker for the better prognosis of IDH mutation glioma, the epigenetic down-regulation of the G0S2 is not the only factor determining the biological characteristics of glioma, however, our results showed that epigenetic G0S2 downregulation following IDH1 mutation effectively inhibits the invasion of GBM cells both in vitro and in vivo. Here, G0S2 is linked to glioblastoma.