Activating mutations in the NLRP3 gene also cause constitutive activation of the NLRP3 inflammasome in patients with a spectrum of autoinflammatory disorders known as cryopyrinopathies or cryopyrin-associated periodic syndromes (CAPS), which include neonatal-onset multisystem inflammatory disease (NOMID), Muckle-Wells syndrome (MWS), and familial cold autoinflammatory syndrome (FCAS) [5, 6]. The gene discussed is NLRP3; the disease is CINCA syndrome.