Moreover, B1 B cells have been shown to class-switch and contribute to serum IgG1, IgG2a and IgA to influenza (Baumgarth et al., 2005), and IgG-producing B1a B cells have been shown to accumulate in the spleen of a mouse model of systemic lupus erythematosus (Enghard et al., 2010). This evidence concerns the gene CD79A and influenza.