Apart from its role in extracellular matrix (ECM) remodeling through crosslinking of collagens and elastin, LOXL2 also regulates a variety of intracellular signaling pathways involved in cell proliferation, differentiation, tumor metastasis, and epithelial‐to‐mesenchymal transition (EMT) (Ahn, Dong, & Oshima, 2013; Chang, Nicolau, & Cox, 2013; Herranz, Dave, & Millanes‐Romero, 2016; Iturbide, Pascual‐Reguant, & Fargas, 2015; Peinado, Portillo, & Cano, 2005). This evidence concerns the gene LOXL2 and neoplasm.