As results, the levels of IL-1β, IL-6, and TNF-α were markedly up-regulated in the DKD renal tissue, but they were decreased to 0.4–0.68-fold, 0.43–0.59-fold and 0.39–0.85-fold after the COD treatment for 7, 15 and 30 days, respectively. This evidence concerns the gene IL1B and diabetic kidney disease.