Defining ageing is in itself challenging, and among many cell types, neuronal ageing has been characterised by various markers of senescence, loss of nuclear lamina (providing mechanical stability and epigenetic regulation and linked with premature ageing, for example progerin in Hutchinson-Gilford Progeria syndrome), loss of heterochromatin markers (demonstrating DNA damage) [34, 35] in addition to other types of oxidative stress. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.