KLK3 and posterior cortical atrophy: Turning findings into clinical practice, in a 70 years old man with PSA 6 ng/ml and normal DRE, the estimated probability of harboring PCa is 27% in case of PVol 60 ml and PVR 80 ml, as opposed to 63% in case of PVol 30 ml and PVR 0 ml; the estimated probability of harboring CSPCa in the above-mentioned conditions is 11 and 33%, respectively.