KLK3 and posterior cortical atrophy: ROC curve analysis demonstrated that the addition of the BPO-related parameters PVol and PVR increased the AUC of the model based on standard variables (age, PSA and DRE status) from 0.664 to 0.768 in predicting PCa and from 0.7365 to 0.8002 in predicting CSPCa (Figure 1).