Given the controversy surrounding the role of PKM2 in pancreatic tumors, we evaluated the importance of PKM2 in PDAC by crossing mice harboring a conditional Pkm2 allele [14] to the LSL-KrasG12D/+;Trp53flox/flox;Pdx-1-Cre (KP−/−C) mouse PDAC model [32]. This evidence concerns the gene PKM and pancreatic neoplasm.