PKM and pancreatic neoplasm: As expected, the analysis of pancreatic tumors showed that KP−/−C;Pkm2+/+ tumors expressed almost exclusively PKM2 (Fig. 3a), whereas consistent with our genomic DNA analysis, tumors from KP−/−C;Pkm2flox/flox mice showed no evidence of PKM2 expression in most cells (Fig. 3a).