PON1 and hypertensive disorder: The development of HBP is associated with other factors, such as increased reactive oxygen species (ROS) and oxidative stress.8,9 ROS contribute to decreased vasodilation and hypertension through their reaction with nitric oxide (NO), their formation of peroxynitrite, and their impairment of endothelial activity.10 In obese people, high serum low-density lipoprotein (LDL) is expected to result in high levels of lipid peroxidation,11 which highlights the importance of paraoxonase-1 (PON-1).