Given the great diversity of results in relation to IL-1 polymorphisms, an interesting review by Bormann et al. (15) divided the results obtained by different groups of researchers into four types: 1) those that do not find a statistically significant relationship between polymorphisms of IL-1 and peri-implantitis, 2) those concluding that there is an uncertain relationship, 3) those that show a significant relationship and 4) those that report a relationship only under the influence of certain added risk factors (e.g., tobacco use). This evidence concerns the gene IL1B and Peri-Implantitis.