Casado et al. (39) in a sample of 103 patients (also of Brazilian origin; 52 healthy and 51 with peri-implant/periodontal pathology), found a positive relationship between the presence of a GG genotype in the IL-6 (174-) G/C region and risk of peri-implantitis. This evidence concerns the gene IL6 and Peri-Implantitis.