CXCR2 and asthma: In a phase 2 study of patients with moderate to severe asthma with high neutrophils counts at baseline (> 40%), CXCR2 antagonist SCH527123 reduced sputum neutrophils counts by 36.3% compared to a 6.7% increase in the placebo group (P = 0.03), but only a trend towards improved asthma control was observed [73].