Regarding urinary tract cancer (including renal pelvis, urothelial and bladder cancer but excluding prostate cancer), other studies have indicated a cumulative risk of 2–12% up to 70 years of age overall, with the highest risk (7–28%) in men with pathogenic MSH2 variants [7, 16, 24–26]. The gene discussed is MSH2; the disease is Familial prostate cancer.