Insufficient autophagy, including mitophagy, has been implicated to IPF pathogenesis, and special attention has been paid to PINK1-PARK2-mediated mitophagy in terms of regulating cell fate for both epithelial cells and fibroblasts [20, 23, 40, 69] (Table 1). This evidence concerns the gene PRKN and idiopathic pulmonary fibrosis.