In this review, we focus on dysregulation of mechanisms for mitochondrial integrity, including PINK1-PARK2-dependent mitophagy in association with progression of cellular senescence, cell death, and myofibroblast differentiation as a part of pathogenesis of aging-associated pulmonary disorders, represented by chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Here, PRKN is linked to chronic obstructive pulmonary disease.