In a model of ovarian carcinoma in rats, melatonin (dose: 200 μg/100 g of body weight, administered from 60 days) inhibited the phosphorylation of AKT and mTOR [110], diminished the levels of TLR4, MyD88, IkKα, NF-κB, TRIF, and IRF-3 [111], and promoted apoptosis through the upregulation of p53, BAX, and caspase-3 and downregulation of Bcl-2 and survivin [112]. Here, CASP3 is linked to ovarian carcinoma.